JRC scientists have been developing and optimising animal-free testing strategies for the identification of chemicals with the potential to cause skin allergy, as a contribution towards international efforts aimed at fulfilling regulatory information requirements on chemical safety while at the same time reducing or avoiding the use of vertebrate animals.
Traditionally, this information has been obtained by performing an animal test, such as the Local Lymph Node Assay (LLNA) in mice. However, for scientific and animal welfare reasons, regulatory bodies are increasingly requiring that information on skin sensitisation potential is provided instead by mechanistic information generated by using alternative (non-animal) test methods.
Further information: Optimised strategies for the identification of skin sensitising chemicals
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